Medeama lost 1-0 at Nsoatreman FC on match day -22 of the Ghana Premier League on Sunday.
Stephen Diyou’s strike six minutes into injury time in the first half separated the two sides at the Nana Konamansah Park.
The defeat is a drawback for coach Nebojsa Kapor – whose side has struggled to win in their recent away matches.
Medeama coach Nebojsa Kapor made one change to the side that beat Bechem United at home last Thursday.
The Mauve and Yellow were without influential defender Nurudeen Abdulai as Baba Musah Abdulai and Kobina Amoah paired at the heart of defence.
The win leaves Nsoatreman FC fourth on the table with 33 points, four more than their opponent in 9th place.