Goalkeeper Boris Mandjui has been handed his first start since March after being named in the starting X1 against Asante Kotoko on Saturday.
The Ivorian replaces Kofi Mensah as the Mauve and Yellows go in search of their second home win of the season.
Defender Baba Abdulai Musah will captain the team with substantive skipper Kwasi Donsu starting from the bench.
Baba will partner Nurudeen Abdulai at the heart of defence while Fatawu Sulemana has maintained his place in the team.
Youngster Moro Mukhtar will play his second competitive game for the senior side after he impressed heavily against Great Olympics.
Hafiz Mohammed Akadom is also in the starting line-up.
Prosper Boakye and Manuel Mantey will play at the heart of midfield with Derric Fordjuor deployed on the wings.
Coach David Duncan has partnered Hans Kwoffie and Kofi Ansu Patric in attack.
Medeama will be aiming to end three successive defeats when they host Asante Kotoko at the Akoon Park.
Medeama Starting XI
Boris Mandjui Jnr, Moro Mukhar, Fatawu Sulemana, Nurudeen Abdulai, Baba Musah Abdulai, Hafiz Mohammed, Manuel Mantey, Prosper Boakye, Derrick Fordjuor, Kofi Ansu Patric, Hans Kwoffie.
Appiah Kubi, Agyei Boakye, Zakaria Mumuni, Ebenezer Achkabi, Theophilus Anobah, Vincent Atingah, Benjamin Abaidoo, Ishmael Hammond, Kwasi Donsu.